BL1102 Biochemistry and Organisation of Cells

Semester I, 2000/01

Module lecturer: A/P Yeoh Hock Hin

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Topics	Suggested Reading
Cellular Structure and Function Basic properties of cells Prokaryotes and eukaryotes Animals and plant cells, Viruses Microscopy To website	McKee T and McKee JR, (1999) Biochemistry Chapter 2 Becker, Reece and Poenie, (1996) The World of the Cell, Chapter 4 Garrett and Grisham, Biochemistry, (1995) Chapter 1 Voet and Voet, (1995) Biochemistry, Chapter 1
Organelles in animals and plant cells Various organelles and their functions To website	McKee T and McKee JR, (1999) Biochemistry Chapter 2 Becker, Reece and Poenie, (1996) The World of the Cell, Chapter 4 Garrett and Grisham, Biochemistry, (1995) Chapter 1 Voet and Voet, (1995) Biochemistry, Chapter 1
Structure and function of membrane Membrane composition Movements of substances across cell membranes To website	McKee T and McKee JR, (1999) Biochemistry Chapter 9, p 235 Becker, Reece and Poenie, (1996) The World of the Cell, Chapter 7, p 167; Chapter 8, p 197 Garrett and Grisham, Biochemistry, (1995) Chapter 9, p 291 Voet and Voet, (1995) Biochemistry, Chapter 11, p 290; Chapter 18, p 513
Chloroplast structure and function Including types of photosynthesis and overall picture of light reactions and Calvin cycle To website	McKee T and McKee JR, (1999) Biochemistry Chapter 12 Becker, Reece and Poenie, (1996) The World of the Cell, Chapter 7, p 167; Chapter 13 Garrett and Grisham, Biochemistry, (1995) Chapter 22 Voet and Voet, (1995) Biochemistry, Chapter 22
Amino Acids and Proteins (3) Classification Modified amino acids in proteins Acid-base properties Chemical reactions To website	McKee T and McKee JR, (1999) Biochemistry Chapter 5 p 79 Garrett and Grisham, Biochemistry, (1995) Chapter 3, p 55 Voet and Voet, (1995) Biochemistry, Chapter 4, p 56
Peptides (2/3) Nature of peptide bonds Properties To website	McKee T and McKee JR, (1999) Biochemistry Chapter 5 p 79 Garrett and Grisham, Biochemistry, (1995) Chapter 4, p 81 Voet and Voet, (1995) Biochemistry, Chapter 7, p 141
Proteins (3/3) Simple and conjugated proteins Globular and fibrous proteins Structural organisation - primary, secondary, tertiary, quaternary (brief) Protein denaturation To website	McKee T and McKee JR, (1999) Biochemistry Chapter 5 p 79 Garrett and Grisham, Biochemistry, (1995) Chapter 4, p 81 Voet and Voet, (1995) Biochemistry, Chapter 7, p 141
Enzymes (1/2) Properties of enzymes How enzymes work Factors affecting reaction velocity : substrate concentration, temperature, pH To website	McKee T and McKee JR, (1999) Biochemistry Chapter 6 p 119 Garrett and Grisham, Biochemistry, (1995) Chapter 11, p 352 Voet and Voet, (1995) Biochemistry, Chapter 12, p 332; Chapter 13, p 345
Enzyme (2/2) Michaelis-Menten equation Inhibition of enzyme activity (competitive/noncompetitive inhibition) To website	McKee T and McKee JR, (1999) Biochemistry Chapter 6 p 119 Garrett and Grisham, Biochemistry, (1995) Chapter 11, p 352 Voet and Voet, (1995) Biochemistry, Chapter 13, p 345
Nucleic acids (1/3) Relationship between nucleic acids and proteins Localisation of nucleic acids Composition of nucleic acids Properties of purines and pyrimidines To website	McKee T and McKee JR, (1999) Biochemistry Chapter 16 p 459 Garrett and Grisham, Biochemistry, (1995) Chapter 6, p 181 Voet and Voet, (1995) Biochemistry, Chapter 28, p 849
Nucleic acids (2/3) Different structures of nucleic acids Forces that stabilise these structures Knowledge of nucleotide structure relevant to the above To website	McKee T and McKee JR, (1999) Biochemistry Chapter 16 p 459 Garrett and Grisham, Biochemistry, (1995) Chapter 6, p 181 Voet and Voet, (1995) Biochemistry, Chapter 28, p 849
Nucleic acids (3/3) Properties of nucleic acids Usefulness in understanding these properties How they are used for genetic engineering To website	McKee T and McKee JR, (1999) Biochemistry Chapter 16 p 459 Garrett and Grisham, Biochemistry, (1995) Chapter 6, p 181 Voet and Voet, (1995) Biochemistry, Chapter 28, p 849
Lipids (1/3) Definition of lipid and ability to distinguish them Appreciation of wide variation in types of lipids Functions and importance How to put order into heterogenous group of compounds To website	McKee T and McKee JR, (1999) Biochemistry Chapter 9 p 216-235 Garrett and Grisham, Biochemistry, (1995) Chapter 9, p 276-291 Voet and Voet, (1995) Biochemistry, Chapter 11, p 277-284
Lipids (2/3) Fatty acids – its importance, localisation and occurrences Chemistry (structures and properties) Rules regarding nomenclature To website	McKee T and McKee JR, (1999) Biochemistry Chapter 9 p 216-235 Garrett and Grisham, Biochemistry, (1995) Chapter 9, p 276-291 Voet and Voet, (1995) Biochemistry, Chapter 11, p 277-284
Lipids (3/3) Fatty acid catabolism Mobilisation of lipids b-oxidation and ATP production (only for saturated fatty acids) To website	McKee T and McKee JR, (1999) Biochemistry Chapter 10 p 250 Garrett and Grisham, Biochemistry, (1995) Chapter 23, p 731 Voet and Voet, (1995) Biochemistry, Chapter 23, p 662
Carbohydrates (1/4) Classification Distinguish between aldose and ketose Fischer projection Properties of mono/s Know some common examples of di/s and oligo/s Structure function relationship of some important poly/s To website	McKee T and McKee JR, (1999) Biochemistry Chapter 7 p 151 Garrett and Grisham, Biochemistry, (1995) Chapter 10, p 310 Voet and Voet, (1995) Biochemistry, Chapter 10, p 251
Carbohydrates (2/4) Glycolysis Key features Localisation Regulation Purpose Importance To website	McKee T and McKee JR, (1999) Biochemistry Chapter 8 p 181 Garrett and Grisham, Biochemistry, (1995) Chapter 18, p 570 Voet and Voet, (1995) Biochemistry, Chapter 16, p 444
Carbohydrates (3/4) TCA cycle Key features Localisation Regulation Purpose Role in relation to synthesis of other molecules To website	McKee T and McKee JR, (1999) Biochemistry Chapter 11 p 289 Garrett and Grisham, Biochemistry, (1995) Chapter 19, p 600 Voet and Voet, (1995) Biochemistry, Chapter 19, p 538
Carbohydrate (4/4) Calvin cycle Types of carbon fixation, C3, C4 and CAM	McKee T and McKee JR, (1999) Biochemistry Chapter 12 p 331 Garrett and Grisham, Biochemistry, (1995) Chapter 22, 699 Voet and Voet, (1995) Biochemistry, Chapter 22, p 627
Application of biological processes (1/2) Industrial applications of enzymes Basis To website	Chaplin and Bucke (1990) Enzyme Technology, p 138
Biosensors (2/2) Principle Applications - glucose biosensor To website	Chaplin and Bucke (1990) Enzyme Technology, p 197

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